Even without two starters, the defense played its most impressive game of the season. The 49ers (1-2) were held to 254 yards on offense and converted just 3-of-12 third down attempts. The Colts also forced two turnovers in the fourth quarter.
Colin Kaepernick completed under 50-percent of his passes and was unable to find room to run, scrambling for just 20 yards. The Colts defense harried Kaepernick all day, sacking him three times and hitting him three more times.
A 14-point fourth quarter sealed the victory for the Colts who dominated the field all game.
Indianapolis was able to dominate the 49ers on the ground, amassing 179 yards. Ahmad Bradshaw got the bulk of the carries and rushed for 95 yards and a touchdown.
Trent Richardson made his debut in a Colts uniform, but was held to limited reps. He had 13 carries for 35 yards and a touchdown.
Andrew Luck played second fiddle to the power run game. He was 18-for-27 for 164 yards. He also had 24 yards rushing and a touchdown.
Punter Pat McAfee was the unsung hero of the day, continually pinning the 49ers deep in their own territory and giving the defense the advantage.
The Colts have a bye week as they travel to Jacksonville to face the winless Jaguars next Sunday.
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